Current Evidence-Based Orthobiologics and Stem Cell Care for The Musculoskeletal System

Orthobiologics are defined as biological substances used to speed up the healing process of musculoskeletal injuries and conditions. The use of orthobiologics is a new, developing area in orthopaedics that’s being actively researched. Since orthobiologics were developed relatively recently, there are fewer clinical studies for them than traditional medical treatments. 

That said, there are evidence-based orthobiologics and stem cell treatments available today to support healing and recovery in the musculoskeletal system. 

Evidence-Based Orthobiologics


PRP stands for platelet-rich plasma, and it’s an orthobiologic that has shown impressive results for supporting healing in the musculoskeletal system – namely, the tendons. PRP consists of the platelets found in the patient’s own blood. Platelets carry crucial proteins and growth factors that, once injected directly into the site of the injury, can ease pain and inflammation while directing tissue healing. 

The tendons receive minimal blood flow. Injured tendons benefit significantly from PRP treatment because the platelets deliver essential healing elements to them, which supports long-term healing. 

ReNu Stem Cell Treatment

ReNu is a cutting-edge orthobiologic that’s most commonly used to treat osteoarthritis. This single-injection treatment is made up of human amniotic fluid and tissues. These substances contain growth factors, stem cells, and extracellular matrix compounds. When the injection is directed into an area of injured tissue, the stem cells aid the healing process, reduce inflammation, and, in the case of osteoarthritis, inhibit joint deterioration. 

While ReNu is frequently used as an orthobiologic for osteoarthritis, it can also be used for orthopaedic conditions and injuries, including bursitis, tendinosis, plantar fasciitis, and a torn rotator cuff. It’s been shown to help patients delay or entirely avoid surgery for relief from musculoskeletal concerns. 

If you’re interested in the currently available, evidence-based orthobiologics for musculoskeletal conditions and injuries, contact Suncoast Orthopaedic Surgery and Sports Medicine today.